However low-cost medications are able to reduce mortality and improve the quality of life of patients with HF. There is some evidence on effective drugs against the parasite in the chronic form of the disease capable of preventing long-term adverse outcomes, but it is still limited. HF is one of major causes of the death of patients with ChD. Although some develop only conduction defects and mild segmental wall motion abnormalities, others develop severe symptoms of heart failure (HF), thromboembolic phenomena, and life threatening ventricular arrhythmias. The majority (60%–70%) of infected individuals remain asymptomatic throughout life. ChD is a heterogeneous condition with a wide variation in its clinical course and prognosis. The model adjusted for the male sex and elevated NT-proBNP had a higher accuracy of 0.89 and an AUC of 0.874.Ĭhagas disease (ChD) is caused by the protozoan parasite Trypanosoma cruzi and continues to be a health problem despite the control of its transmission. The model adjusted for the male sex and QRS ≥ 120ms improved the AUC to 0.859. The AI algorithm identified LVSD among ChD patients with an odds ratio of 63.3 (95% CI 32.3–128.9), a sensitivity of 73%, a specificity of 83%, an overall accuracy of 83%, and a negative predictive value of 97% the AUC was 0.839. Most patients had major ECG abnormalities (59.5%). The model was enriched with NT-proBNP plasma levels, male sex, and QRS ≥ 120ms.Īmong the 1,304 participants of this study, 67% were women, median age of 60 there were 93 (7.1%) individuals with LVSD. The diagnostic performance of the AI-enabled ECG to detect LVSD was tested using an echocardiogram as the gold standard to detect LVSD, defined as an ejection fraction <40%. The digital ECGs of the participants were submitted to the analysis of the trained machine to detect LVSD. This is a cross-sectional study of ECG obtained from a large cohort of patients with ChD named São Paulo-Minas Gerais Tropical Medicine Research Center (SaMi-Trop) Study.